Sign on
ADS Classic is now deprecated. It will be completely retired in October 2019. Please redirect your searches to the new ADS modern form or the classic form. More info can be found on our blog.

SAO/NASA ADS General Science Abstract Service


· Find Similar Abstracts (with default settings below)
· Electronic Refereed Journal Article (HTML)
· References in the article
· Citations to the Article (49) (Citation History)
· Refereed Citations to the Article
· Also-Read Articles (Reads History)
·
· Translate This Page
Title:
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
Authors:
Archin, N. M.; Liberty, A. L.; Kashuba, A. D.; Choudhary, S. K.; Kuruc, J. D.; Crooks, A. M.; Parker, D. C.; Anderson, E. M.; Kearney, M. F.; Strain, M. C.; Richman, D. D.; Hudgens, M. G.; Bosch, R. J.; Coffin, J. M.; Eron, J. J.; Hazuda, D. J.; Margolis, D. M.
Affiliation:
AA(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA), AB(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA), AC(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA), AD(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA), AE(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA), AF(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA), AG(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA), AH(HIV Drug Resistance Program, NCI, NIH, Frederick, Maryland 21702, USA), AI(HIV Drug Resistance Program, NCI, NIH, Frederick, Maryland 21702, USA), AJ(VA San Diego Healthcare System and University of California San Diego, San Diego, California 92093, USA), AK(VA San Diego Healthcare System and University of California San Diego, San Diego, California 92093, USA), AL(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA), AM(Harvard School of Public Health, Boston, Massachusetts 02115, USA), AN(HIV Drug Resistance Program, NCI, NIH, Frederick, Maryland 21702, USA), AO(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA), AP(Merck Research Laboratories, White Horse Junction, Pennsylvania 08889, USA), AQ(The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA; )
Publication:
Nature, Volume 487, Issue 7408, pp. 482-485 (2012). (Nature Homepage)
Publication Date:
07/2012
Origin:
NATURE
Abstract Copyright:
(c) 2012: Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
DOI:
10.1038/nature11286
Bibliographic Code:
2012Natur.487..482A

Abstract

Despite antiretroviral therapy, proviral latency of human immunodeficiency virus type 1 (HIV-1) remains a principal obstacle to curing the infection. Inducing the expression of latent genomes within resting CD4+ T cells is the primary strategy to clear this reservoir. Although histone deacetylase inhibitors such as suberoylanilide hydroxamic acid (also known as vorinostat, VOR) can disrupt HIV-1 latency in vitro, the utility of this approach has never been directly proven in a translational clinical study of HIV-infected patients. Here we isolated the circulating resting CD4+ T cells of patients in whom viraemia was fully suppressed by antiretroviral therapy, and directly studied the effect of VOR on this latent reservoir. In each of eight patients, a single dose of VOR increased both biomarkers of cellular acetylation, and simultaneously induced an increase in HIV RNA expression in resting CD4+ cells (mean increase, 4.8-fold). This demonstrates that a molecular mechanism known to enforce HIV latency can be therapeutically targeted in humans, provides proof-of-concept for histone deacetylase inhibitors as a therapeutic class, and defines a precise approach to test novel strategies to attack and eradicate latent HIV infection directly.
Bibtex entry for this abstract   Preferred format for this abstract (see Preferences)


Find Similar Abstracts:

Use: Authors
Title
Abstract Text
Return: Query Results Return    items starting with number
Query Form
Database: Astronomy
Physics
arXiv e-prints