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Term Information

Data health 
Accession
GO:0000165
Name
MAPK cascade
Ontology
biological_process
Synonyms
MAP kinase cascade, MAP kinase kinase kinase cascade, MAPK signal transduction, MAPKKK cascade, mitogen-activated protein kinase cascade, MAPK signaling, MAPK signalling, ERK/MAPK cascade, MAPKKK cascade during sporulation
Alternate IDs
None
Definition
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. Source: PMID:9561267, PMID:20811974, GOC:mtg_signaling_feb11, GOC:bf
Comment
MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
History
See term history for GO:0000165 at QuickGO
Subset
None

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Graph of GO:0000165 from QuickGO

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Parents of MAPK cascade (GO:0000165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MAPK cascade [RO:0002160 relation] RO:0002160  Eukaryota (NCBITaxon:2759)
MAPK cascade [is_a relation] is_a  signal transduction by protein phosphorylation (GO:0023014)
MAPK cascade [is_a relation] is_a  intracellular signal transduction (GO:0035556)
Children of MAPK cascade (GO:0000165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MAP kinase kinase kinase kinase activity (GO:0008349) [BFO:0000050 relation] BFO:0000050  MAPK cascade
stress-activated MAPK cascade (GO:0051403) [is_a relation] is_a  MAPK cascade
MAP kinase kinase activity (GO:0004708) [BFO:0000050 relation] BFO:0000050  MAPK cascade
MAP kinase kinase kinase activity (GO:0004709) [BFO:0000050 relation] BFO:0000050  MAPK cascade
ERK1 and ERK2 cascade (GO:0070371) [is_a relation] is_a  MAPK cascade
MAPK cascade involved in innate immune response (GO:0035420) [is_a relation] is_a  MAPK cascade
negative regulation of MAPK cascade (GO:0043409) [RO:0002212 relation] RO:0002212  MAPK cascade
regulation of MAPK cascade (GO:0043408) [RO:0002211 relation] RO:0002211  MAPK cascade
ERK5 cascade (GO:0070375) [is_a relation] is_a  MAPK cascade
positive regulation of MAPK cascade (GO:0043410) [RO:0002213 relation] RO:0002213  MAPK cascade
pheromone response MAPK cascade (GO:0071507) [is_a relation] is_a  MAPK cascade
MAP kinase activity (GO:0004707) [BFO:0000050 relation] BFO:0000050  MAPK cascade
MAPK cascade involved in ascospore formation (GO:1903695) [is_a relation] is_a  MAPK cascade
non-canonical Wnt signaling pathway via MAPK cascade (GO:0038030) [BFO:0000051 relation] BFO:0000051  MAPK cascade
MAPK cascade involved in axon regeneration (GO:1903616) [is_a relation] is_a  MAPK cascade
epidermal growth factor receptor signaling pathway via MAPK cascade (GO:0038029) [BFO:0000051 relation] BFO:0000051  MAPK cascade