Term Information

Data health 
Accession
GO:0000977
Name
RNA polymerase II regulatory region sequence-specific DNA binding
Ontology
molecular_function
Synonyms
None
Alternate IDs
None
Definition
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. Source: GOC:txnOH
Comment
The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
History
See term history for GO:0000977 at QuickGO
Subset
None

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Parents of RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RNA polymerase II regulatory region sequence-specific DNA binding [is_a relation] is_a  RNA polymerase II regulatory region DNA binding (GO:0001012)
RNA polymerase II regulatory region sequence-specific DNA binding [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding (GO:0000976)
Children of RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of RNA polymerase II regulatory region sequence-specific DNA binding (GO:1903025) [RO:0002211 relation] RO:0002211  RNA polymerase II regulatory region sequence-specific DNA binding
C/EBP complex (GO:1990647) [RO:0002215 relation] RO:0002215  RNA polymerase II regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981) [RO:0002016 relation] RO:0002016  RNA polymerase II regulatory region sequence-specific DNA binding
ATF1-ATF4 transcription factor complex (GO:1990590) [RO:0002215 relation] RO:0002215  RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding (GO:0000978) [is_a relation] is_a  RNA polymerase II regulatory region sequence-specific DNA binding
ATF4-CREB1 transcription factor complex (GO:1990589) [RO:0002215 relation] RO:0002215  RNA polymerase II regulatory region sequence-specific DNA binding
beta-catenin-TCF complex (GO:1990907) [RO:0002215 relation] RO:0002215  RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979) [is_a relation] is_a  RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding (GO:1903026) [RO:0002212 relation] RO:0002212  RNA polymerase II regulatory region sequence-specific DNA binding
upstream stimulatory factor complex (GO:1990378) [RO:0002215 relation] RO:0002215  RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding (GO:1905636) [RO:0002213 relation] RO:0002213  RNA polymerase II regulatory region sequence-specific DNA binding
CHOP-ATF4 complex (GO:1990617) [RO:0002215 relation] RO:0002215  RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980) [is_a relation] is_a  RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding (GO:0001162) [is_a relation] is_a  RNA polymerase II regulatory region sequence-specific DNA binding
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