Term Information

Data health 
Accession
GO:0000987
Name
proximal promoter sequence-specific DNA binding
Ontology
molecular_function
Synonyms
core promoter proximal region sequence-specific DNA binding, promoter proximal region sequence-specific DNA binding, core promoter proximal region DNA binding
Alternate IDs
GO:0001159
Definition
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter. Source: GOC:txnOH, GOC:pg
Comment
The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
History
See term history for GO:0000987 at QuickGO
Subset
None

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Parents of proximal promoter sequence-specific DNA binding (GO:0000987)
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proximal promoter sequence-specific DNA binding [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding (GO:0000976)
Children of proximal promoter sequence-specific DNA binding (GO:0000987)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RNA polymerase I upstream control element sequence-specific DNA binding (GO:0001165) [is_a relation] is_a  proximal promoter sequence-specific DNA binding
bacterial-type proximal promoter sequence-specific DNA binding (GO:0000986) [is_a relation] is_a  proximal promoter sequence-specific DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding (GO:0000978) [is_a relation] is_a  proximal promoter sequence-specific DNA binding
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