Term Information

Data health 
Accession
GO:0001227
Name
DNA-binding transcription repressor activity, RNA polymerase II-specific
Ontology
molecular_function
Synonyms
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription, RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding, RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding, distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific, metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription, metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific, sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription, transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding, transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding, transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
Alternate IDs
GO:0001206, GO:0001214, GO:0001210, GO:0001078
Definition
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units. Source: GOC:txnOH-2018
Comment
Changed term label and definition https://github.com/geneontology/go-ontology/issues/16131 and https://github.com/geneontology/go-ontology/issues/16152 Merge terms see https://github.com/geneontology/go-ontology/issues/16534
History
See term history for GO:0001227 at QuickGO
Subset
None

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Graph of GO:0001227 from QuickGO

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Parents of DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
DNA-binding transcription repressor activity, RNA polymerase II-specific [BFO:0000050 relation] BFO:0000050  negative regulation of transcription by RNA polymerase II (GO:0000122)
DNA-binding transcription repressor activity, RNA polymerase II-specific [is_a relation] is_a  DNA-binding transcription repressor activity (GO:0001217)
DNA-binding transcription repressor activity, RNA polymerase II-specific [is_a relation] is_a  DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)

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