Term Information

Data health 
Accession
GO:0003700
Name
DNA-binding transcription factor activity
Ontology
molecular_function
Synonyms
DNA binding transcription factor activity, gene-specific transcription factor activity, sequence-specific DNA binding transcription factor activity, bacterial-type DNA binding transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity, bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding, bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding, metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding, transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding, transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding, transcription factor activity, metal ion regulated sequence-specific DNA binding, nucleic acid binding transcription factor activity, transcription factor activity
Alternate IDs
GO:0001071, GO:0001204, GO:0001199, GO:0001131, GO:0000130, GO:0001151, GO:0001130
Definition
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. Source: GOC:txnOH-2018
Comment
Curator guidance: Note that most DNA-binding transcription factors do not have enzymatic activity. The presence of specific domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing Myb/SANT and ARID domains, since only a subset of proteins containing these domains are DNA-binding transcription factors for specific genes. Changed definition see https://github.com/geneontology/go-ontology/issues/15704 Merged term see https://github.com/geneontology/go-ontology/issues/16534
History
See term history for GO:0003700 at QuickGO
Subset
goslim_metagenomics
goslim_aspergillus
goslim_chembl
goslim_plant
goslim_generic
goslim_mouse
goslim_agr
goslim_candida
goslim_yeast

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Graph of GO:0003700 from QuickGO

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Parents of DNA-binding transcription factor activity (GO:0003700)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
DNA-binding transcription factor activity [is_a relation] is_a  transcription regulator activity (GO:0140110)
DNA-binding transcription factor activity [BFO:0000050 relation] BFO:0000050  regulation of transcription, DNA-templated (GO:0006355)
DNA-binding transcription factor activity [RO:0002016 relation] RO:0002016  transcription regulatory region sequence-specific DNA binding (GO:0000976)
Children of DNA-binding transcription factor activity (GO:0003700)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mitochondrial sequence-specific DNA-binding transcription factor activity (GO:0034246) [is_a relation] is_a  DNA-binding transcription factor activity
DNA-binding transcription activator activity (GO:0001216) [is_a relation] is_a  DNA-binding transcription factor activity
positive regulation of DNA-binding transcription factor activity (GO:0051091) [RO:0002213 relation] RO:0002213  DNA-binding transcription factor activity
DNA-binding transcription factor binding (GO:0140297) [RO:0002233 relation] RO:0002233  DNA-binding transcription factor activity
regulation of DNA-binding transcription factor activity (GO:0051090) [RO:0002211 relation] RO:0002211  DNA-binding transcription factor activity
transcription factor complex (GO:0005667) [RO:0002215 relation] RO:0002215  DNA-binding transcription factor activity
negative regulation of DNA-binding transcription factor activity (GO:0043433) [RO:0002212 relation] RO:0002212  DNA-binding transcription factor activity
ligand-activated transcription factor activity (GO:0098531) [is_a relation] is_a  DNA-binding transcription factor activity
DNA-binding transcription repressor activity (GO:0001217) [is_a relation] is_a  DNA-binding transcription factor activity
DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981) [is_a relation] is_a  DNA-binding transcription factor activity
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