Term Information

Data health 
Accession
GO:0003712
Name
transcription coregulator activity
Ontology
molecular_function
Synonyms
transcription cofactor activity, transcriptional co-regulator, RNA polymerase II transcriptional cofactor activity
Alternate IDs
GO:0001104, GO:0016455
Definition
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators. Source: GOC:txnOH-2018, PMID:10213677, PMID:16858867, Wikipedia:Transcription_coregulator, PMID:24203923, PMID:25957681
Comment
Curator guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity. Fixed term label and definition, see https://github.com/geneontology/go-ontology/issues/15998; Changed parents, see https://github.com/geneontology/go-ontology/issues/15536; Merged children terms, see https://github.com/geneontology/go-ontology/issues/15665
History
See term history for GO:0003712 at QuickGO
Subset
None

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Parents of transcription coregulator activity (GO:0003712)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription coregulator activity [is_a relation] is_a  transcription regulator activity (GO:0140110)
transcription coregulator activity [BFO:0000050 relation] BFO:0000050  regulation of nucleic acid-templated transcription (GO:1903506)
Children of transcription coregulator activity (GO:0003712)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription coactivator activity (GO:0003713) [is_a relation] is_a  transcription coregulator activity
transcription corepressor activity (GO:0003714) [is_a relation] is_a  transcription coregulator activity
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