Term Information

Data health 
Accession
GO:0004252
Name
serine-type endopeptidase activity
Ontology
molecular_function
Synonyms
blood coagulation factor activity, serine elastase activity
Alternate IDs
None
Definition
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). Source: http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, GOC:mah, ISBN:0716720094
Comment
None
History
See term history for GO:0004252 at QuickGO
Subset
goslim_chembl

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Graph of GO:0004252 from QuickGO

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Parents of serine-type endopeptidase activity (GO:0004252)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
serine-type endopeptidase activity [is_a relation] is_a  endopeptidase activity (GO:0004175)
serine-type endopeptidase activity [is_a relation] is_a  serine-type peptidase activity (GO:0008236)
Children of serine-type endopeptidase activity (GO:0004252)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
serine-type endopeptidase complex (GO:1905370) [RO:0002215 relation] RO:0002215  serine-type endopeptidase activity
serine-type endopeptidase inhibitor activity (GO:0004867) [RO:0002212 relation] RO:0002212  serine-type endopeptidase activity
positive regulation of serine-type endopeptidase activity (GO:1900005) [RO:0002213 relation] RO:0002213  serine-type endopeptidase activity
regulation of serine-type endopeptidase activity (GO:1900003) [RO:0002211 relation] RO:0002211  serine-type endopeptidase activity
negative regulation of serine-type endopeptidase activity (GO:1900004) [RO:0002212 relation] RO:0002212  serine-type endopeptidase activity
EC
3.4.21
Reactome
R-HSA-8874204
R-HSA-8874206
R-HSA-8874205
R-HSA-171288
R-HSA-1474197
R-HSA-381500
R-HSA-159728
R-HSA-381466
R-HSA-173745
R-HSA-2168960
R-HSA-1592362
R-HSA-173626
R-HSA-166817
R-HSA-1181152
R-HSA-158750
R-HSA-1602473
R-HSA-381461
R-HSA-174551
R-HSA-5607002
R-HSA-2172405
R-HSA-422051
R-HSA-1604360
R-HSA-2022411
R-HSA-2471842
R-HSA-977371
R-HSA-140664
R-HSA-158747
R-HSA-3785684
R-HSA-140700
R-HSA-140823
R-HSA-159796
R-HSA-158982
R-HSA-158744
R-HSA-1604763
R-HSA-183130
R-HSA-1602466
R-HSA-2482180
R-HSA-1604368
R-HSA-3928657
R-HSA-9023633
R-HSA-1566979
R-HSA-9023196
R-HSA-170844
R-HSA-9023632
R-HSA-2129357
R-HSA-1604359
R-HSA-1566981
R-HSA-6800198
R-HSA-1602458
R-HSA-6801687
R-HSA-381446
R-HSA-140777
R-HSA-158333
R-HSA-173680
R-HSA-1604752
R-HSA-183122
R-HSA-2214330
R-HSA-166753
R-HSA-5210935
R-HSA-400492
R-HSA-9023627
R-HSA-139893
R-HSA-158164
R-HSA-9023626
R-HSA-1912372
R-HSA-400496
R-HSA-159771
R-HSA-2168923
R-HSA-8865275
R-HSA-1592297
R-HSA-381798
R-HSA-8865276
R-HSA-1454843
R-HSA-140769
R-HSA-159773
R-HSA-1604741
R-HSA-422021
R-HSA-1604690
R-HSA-1592278
R-HSA-1592314
R-HSA-1592316
R-HSA-9033530
R-HSA-9023178
R-HSA-1592436
R-HSA-1566962
R-HSA-5578783
R-HSA-6800299
R-HSA-140599
R-HSA-2534206
R-HSA-158311
R-HSA-2534160
R-HSA-141040
R-HSA-187020
R-HSA-158313
R-HSA-1604732
R-HSA-1912369
R-HSA-140870
R-HSA-1604731
R-HSA-5210912
R-HSA-9033524
R-HSA-9033529
R-HSA-8850831
R-HSA-9033520
R-HSA-381135
R-HSA-1604722
R-HSA-3814820
R-HSA-1592270
R-HSA-6800200
R-HSA-1592398
R-HSA-8849857
R-HSA-1799329
R-HSA-9033490
R-HSA-158300
R-HSA-382061
R-HSA-977615
R-HSA-158942
R-HSA-265301
R-HSA-9033515
R-HSA-5691512
R-HSA-1604712
R-HSA-140696
R-HSA-141026
R-HSA-1655842
R-HSA-163843
R-HSA-158419
R-HSA-2514823
R-HSA-140736
R-HSA-166792
R-HSA-3788061
R-HSA-158137
R-HSA-114697
R-HSA-2534260
R-HSA-6807224
R-HSA-159868
R-HSA-8852716
R-HSA-9033506
R-HSA-8849826
R-HSA-8874212
R-HSA-2471621
R-HSA-3266557
R-HSA-8855825
R-HSA-140840
R-HSA-173631
R-HSA-1592371
R-HSA-163798
R-HSA-158925
R-HSA-8874186
R-HSA-5591040
R-HSA-976743
R-HSA-1602484
R-HSA-158766
R-HSA-159733
R-HSA-1602488
R-HSA-186785
R-HSA-2514772
R-HSA-400459