Term Information

Data health 
Accession
GO:0007165
Name
signal transduction
Ontology
biological_process
Synonyms
signaling pathway, signalling pathway, signaling cascade, signalling cascade
Alternate IDs
GO:0023033
Definition
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. Source: GOC:mtg_signaling_feb11, GOC:go_curators
Comment
Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
History
See term history for GO:0007165 at QuickGO
Subset
goslim_metagenomics
goslim_aspergillus
goslim_chembl
goslim_plant
goslim_generic
goslim_candida

Filter results

Loading...
pending...
View this term in QuickGO.

Graph of GO:0007165 from QuickGO

Additional external viewing options
Additional internal viewing options
Parents of signal transduction (GO:0007165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
signal transduction [BFO:0000050 relation] BFO:0000050  cellular response to stimulus (GO:0051716)
signal transduction [BFO:0000050 relation] BFO:0000050  signaling (GO:0023052)
signal transduction [is_a relation] is_a  regulation of cellular process (GO:0050794)
signal transduction [is_a relation] is_a  cellular process (GO:0009987)
signal transduction [BFO:0000050 relation] BFO:0000050  cell communication (GO:0007154)
Children of signal transduction (GO:0007165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of signal transduction (GO:0009967) [RO:0002213 relation] RO:0002213  signal transduction
hormone-mediated signaling pathway (GO:0009755) [is_a relation] is_a  signal transduction
regulation of signal transduction (GO:0009966) [RO:0002211 relation] RO:0002211  signal transduction
extracellular ATP signaling (GO:0106167) [is_a relation] is_a  signal transduction
signal transduction involved in positive regulation of conjugation with cellular fusion (GO:0032005) [is_a relation] is_a  signal transduction
G protein-coupled receptor signaling pathway (GO:0007186) [is_a relation] is_a  signal transduction
regulation of floral organ abscission by signal transduction (GO:0060863) [is_a relation] is_a  signal transduction
neuronal signal transduction (GO:0023041) [is_a relation] is_a  signal transduction
defense response signaling pathway, resistance gene-dependent (GO:0009870) [is_a relation] is_a  signal transduction
carbohydrate mediated signaling (GO:0009756) [is_a relation] is_a  signal transduction
receptor ligand activity (GO:0048018) [BFO:0000050 relation] BFO:0000050  signal transduction
hydrogen peroxide mediated signaling pathway (GO:0071588) [is_a relation] is_a  signal transduction
cell cycle checkpoint (GO:0000075) [RO:0002230 relation] RO:0002230  signal transduction
presynaptic signal transduction (GO:0098928) [is_a relation] is_a  signal transduction
signal transduction by conformational transition (GO:0023045) [is_a relation] is_a  signal transduction
calmodulin dependent kinase signaling pathway (GO:0099004) [is_a relation] is_a  signal transduction
signal transduction involved in regulation of aerobic respiration (GO:1903759) [is_a relation] is_a  signal transduction
ER-nucleus signaling pathway (GO:0006984) [is_a relation] is_a  signal transduction
necroptotic signaling pathway (GO:0097527) [is_a relation] is_a  signal transduction
postsynaptic signal transduction (GO:0098926) [is_a relation] is_a  signal transduction
chloroplast-nucleus signaling pathway (GO:0010019) [is_a relation] is_a  signal transduction
hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) [is_a relation] is_a  signal transduction
apoptotic signaling pathway (GO:0097190) [is_a relation] is_a  signal transduction
negative regulation of signal transduction (GO:0009968) [RO:0002212 relation] RO:0002212  signal transduction
phototransduction (GO:0007602) [is_a relation] is_a  signal transduction
signal transduction involved in cellular response to ammonium ion (GO:1903831) [is_a relation] is_a  signal transduction
defense response signaling pathway, resistance gene-independent (GO:0010204) [is_a relation] is_a  signal transduction
signal transduction by protein phosphorylation (GO:0023014) [is_a relation] is_a  signal transduction
lipoprotein particle mediated signaling (GO:0055095) [is_a relation] is_a  signal transduction
signal transduction in absence of ligand (GO:0038034) [is_a relation] is_a  signal transduction
signal transduction involved in filamentous growth (GO:0001402) [is_a relation] is_a  signal transduction
salicylic acid mediated signaling pathway (GO:0009863) [is_a relation] is_a  signal transduction
immune response-regulating signaling pathway (GO:0002764) [is_a relation] is_a  signal transduction
endoplasmic reticulum unfolded protein response (GO:0030968) [is_a relation] is_a  signal transduction
red or far-red light signaling pathway (GO:0010017) [is_a relation] is_a  signal transduction
ligand-gated ion channel signaling pathway (GO:1990806) [is_a relation] is_a  signal transduction
regulation of blood pressure by chemoreceptor signaling pathway (GO:0010850) [is_a relation] is_a  signal transduction
signal transduction involved in regulation of gene expression (GO:0023019) [is_a relation] is_a  signal transduction
cell surface receptor signaling pathway (GO:0007166) [is_a relation] is_a  signal transduction
sphingolipid mediated signaling pathway (GO:0090520) [is_a relation] is_a  signal transduction
programmed cell death (GO:0012501) [RO:0002224 relation] RO:0002224  signal transduction
SMAD protein signal transduction (GO:0060395) [is_a relation] is_a  signal transduction
intracellular signal transduction (GO:0035556) [is_a relation] is_a  signal transduction
signal transduction involved in morphogenesis checkpoint (GO:1903822) [is_a relation] is_a  signal transduction
intracellular receptor signaling pathway (GO:0030522) [is_a relation] is_a  signal transduction
osmosensory signaling pathway (GO:0007231) [is_a relation] is_a  signal transduction
bile acid signaling pathway (GO:0038183) [is_a relation] is_a  signal transduction
mitochondria-nucleus signaling pathway (GO:0031930) [is_a relation] is_a  signal transduction
MIPS_funcat
30
Wikipedia
Signal_transduction