Term Information

Data health 
Accession
GO:0007186
Name
G protein-coupled receptor signaling pathway
Ontology
biological_process
Synonyms
G protein coupled receptor protein signaling pathway, G protein coupled receptor protein signalling pathway, G-protein coupled receptor protein signal transduction, G-protein coupled receptor protein signaling pathway, G-protein coupled receptor signalling pathway, G-protein-coupled receptor protein signalling pathway, GPCR signaling pathway, GPCR signalling pathway, G-protein coupled receptor signaling pathway via GPCR dimer, dimeric G-protein coupled receptor signaling pathway, dimeric G-protein coupled receptor signalling pathway
Alternate IDs
GO:0038042
Definition
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). Source: Wikipedia:G_protein-coupled_receptor, PMID:24568158, PMID:16902576, GOC:bf, GOC:mah
Comment
None
History
See term history for GO:0007186 at QuickGO
Subset
None

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Parents of G protein-coupled receptor signaling pathway (GO:0007186)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
G protein-coupled receptor signaling pathway [is_a relation] is_a  signal transduction (GO:0007165)
G protein-coupled receptor signaling pathway [RO:0002224 relation] RO:0002224  G protein-coupled receptor activity (GO:0004930)
Children of G protein-coupled receptor signaling pathway (GO:0007186)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
apelin receptor signaling pathway (GO:0060183) [is_a relation] is_a  G protein-coupled receptor signaling pathway
bombesin receptor signaling pathway (GO:0031989) [is_a relation] is_a  G protein-coupled receptor signaling pathway
adrenergic receptor signaling pathway (GO:0071875) [is_a relation] is_a  G protein-coupled receptor signaling pathway
somatostatin receptor signaling pathway (GO:0038169) [is_a relation] is_a  G protein-coupled receptor signaling pathway
ion channel regulator activity involved in G protein-coupled receptor signaling pathway (GO:0099107) [BFO:0000050 relation] BFO:0000050  G protein-coupled receptor signaling pathway
regulation of G protein-coupled receptor signaling pathway (GO:0008277) [RO:0002211 relation] RO:0002211  G protein-coupled receptor signaling pathway
endothelin receptor signaling pathway (GO:0086100) [is_a relation] is_a  G protein-coupled receptor signaling pathway
G protein-coupled glutamate receptor signaling pathway (GO:0007216) [is_a relation] is_a  G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium (GO:1903554) [is_a relation] is_a  G protein-coupled receptor signaling pathway
angiotensin-activated signaling pathway (GO:0038166) [is_a relation] is_a  G protein-coupled receptor signaling pathway
phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200) [is_a relation] is_a  G protein-coupled receptor signaling pathway
complement component C5a signaling pathway (GO:0038178) [is_a relation] is_a  G protein-coupled receptor signaling pathway
tachykinin receptor signaling pathway (GO:0007217) [is_a relation] is_a  G protein-coupled receptor signaling pathway
thyroid-stimulating hormone signaling pathway (GO:0038194) [is_a relation] is_a  G protein-coupled receptor signaling pathway
phospholipase D-activating G protein-coupled receptor signaling pathway (GO:0031583) [is_a relation] is_a  G protein-coupled receptor signaling pathway
follicle-stimulating hormone signaling pathway (GO:0042699) [is_a relation] is_a  G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) [is_a relation] is_a  G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway involved in dauer larval development (GO:1904066) [is_a relation] is_a  G protein-coupled receptor signaling pathway
leukotriene signaling pathway (GO:0061737) [is_a relation] is_a  G protein-coupled receptor signaling pathway
gastric inhibitory peptide signaling pathway (GO:0038192) [is_a relation] is_a  G protein-coupled receptor signaling pathway
cholecystokinin signaling pathway (GO:0038188) [is_a relation] is_a  G protein-coupled receptor signaling pathway
negative regulation of G protein-coupled receptor signaling pathway (GO:0045744) [RO:0002212 relation] RO:0002212  G protein-coupled receptor signaling pathway
thrombin-activated receptor signaling pathway (GO:0070493) [is_a relation] is_a  G protein-coupled receptor signaling pathway
phospholipase C-inhibiting G protein-coupled receptor signaling pathway (GO:0030845) [is_a relation] is_a  G protein-coupled receptor signaling pathway
G protein-coupled serotonin receptor signaling pathway (GO:0098664) [is_a relation] is_a  G protein-coupled receptor signaling pathway
G protein-coupled purinergic receptor signaling pathway (GO:0035588) [is_a relation] is_a  G protein-coupled receptor signaling pathway
luteinizing hormone signaling pathway (GO:0042700) [is_a relation] is_a  G protein-coupled receptor signaling pathway
G protein-coupled receptor activity (GO:0004930) [BFO:0000050 relation] BFO:0000050  G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway involved in heart process (GO:0086103) [is_a relation] is_a  G protein-coupled receptor signaling pathway
rhodopsin mediated signaling pathway (GO:0016056) [is_a relation] is_a  G protein-coupled receptor signaling pathway
thromboxane A2 signaling pathway (GO:0038193) [is_a relation] is_a  G protein-coupled receptor signaling pathway
neuropeptide signaling pathway (GO:0007218) [is_a relation] is_a  G protein-coupled receptor signaling pathway
positive regulation of G protein-coupled receptor signaling pathway (GO:0045745) [RO:0002213 relation] RO:0002213  G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway involved in social behavior (GO:1904068) [is_a relation] is_a  G protein-coupled receptor signaling pathway
ion channel modulating, G protein-coupled receptor signaling pathway (GO:0099105) [is_a relation] is_a  G protein-coupled receptor signaling pathway
protein kinase C-activating G protein-coupled receptor signaling pathway (GO:0007205) [is_a relation] is_a  G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling in absence of ligand (GO:0038035) [is_a relation] is_a  G protein-coupled receptor signaling pathway
gamma-aminobutyric acid signaling pathway (GO:0007214) [is_a relation] is_a  G protein-coupled receptor signaling pathway
G protein-coupled acetylcholine receptor signaling pathway (GO:0007213) [is_a relation] is_a  G protein-coupled receptor signaling pathway
octopamine or tyramine signaling pathway (GO:0007211) [is_a relation] is_a  G protein-coupled receptor signaling pathway
opioid receptor signaling pathway (GO:0038003) [is_a relation] is_a  G protein-coupled receptor signaling pathway
cannabinoid signaling pathway (GO:0038171) [is_a relation] is_a  G protein-coupled receptor signaling pathway
sphingosine-1-phosphate receptor signaling pathway (GO:0003376) [is_a relation] is_a  G protein-coupled receptor signaling pathway
calcitonin family receptor signaling pathway (GO:0097646) [is_a relation] is_a  G protein-coupled receptor signaling pathway
MIPS_funcat
30.01.05.05
30.05.02.24