Term Information

Data health 
Accession
GO:0044212
Name
transcription regulatory region DNA binding
Ontology
molecular_function
Synonyms
regulatory region DNA binding
Alternate IDs
GO:0000975
Definition
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. Source: GOC:jl, GOC:txnOH, SO:0005836
Comment
The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
History
See term history for GO:0044212 at QuickGO
Subset
None

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Parents of transcription regulatory region DNA binding (GO:0044212)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription regulatory region DNA binding [is_a relation] is_a  regulatory region nucleic acid binding (GO:0001067)
transcription regulatory region DNA binding [is_a relation] is_a  DNA binding (GO:0003677)
Children of transcription regulatory region DNA binding (GO:0044212)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription termination site DNA binding (GO:0001160) [is_a relation] is_a  transcription regulatory region DNA binding
enhancer binding (GO:0035326) [is_a relation] is_a  transcription regulatory region DNA binding
negative regulation of transcription regulatory region DNA binding (GO:2000678) [RO:0002212 relation] RO:0002212  transcription regulatory region DNA binding
purine-rich negative regulatory element binding (GO:0032422) [is_a relation] is_a  transcription regulatory region DNA binding
RNA polymerase III regulatory region DNA binding (GO:0001016) [is_a relation] is_a  transcription regulatory region DNA binding
intronic transcription regulatory region DNA binding (GO:0044213) [is_a relation] is_a  transcription regulatory region DNA binding
transcription regulatory region sequence-specific DNA binding (GO:0000976) [is_a relation] is_a  transcription regulatory region DNA binding
chromatin lock complex (GO:0061793) [RO:0002215 relation] RO:0002215  transcription regulatory region DNA binding
core promoter binding (GO:0001047) [is_a relation] is_a  transcription regulatory region DNA binding
positive regulation of transcription regulatory region DNA binding (GO:2000679) [RO:0002213 relation] RO:0002213  transcription regulatory region DNA binding
plastid RNA polymerase regulatory region DNA binding (GO:0001019) [is_a relation] is_a  transcription regulatory region DNA binding
regulation of transcription regulatory region DNA binding (GO:2000677) [RO:0002211 relation] RO:0002211  transcription regulatory region DNA binding
RNA polymerase I regulatory region DNA binding (GO:0001013) [is_a relation] is_a  transcription regulatory region DNA binding
mitochondrial promoter sequence-specific DNA binding (GO:0001018) [is_a relation] is_a  transcription regulatory region DNA binding
RNA polymerase II regulatory region DNA binding (GO:0001012) [is_a relation] is_a  transcription regulatory region DNA binding
bacterial-type RNA polymerase regulatory region DNA binding (GO:0001017) [is_a relation] is_a  transcription regulatory region DNA binding
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