Term Information

Data health 
Accession
GO:0070268
Name
cornification
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability). Source: GOC:krc, PMID:18846107
Comment
None
History
See term history for GO:0070268 at QuickGO
Subset
None

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Parents of cornification (GO:0070268)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cornification [BFO:0000050 relation] BFO:0000050  keratinization (GO:0031424)
cornification [BFO:0000051 relation] BFO:0000051  cornified envelope assembly (GO:1903575)
cornification [is_a relation] is_a  programmed cell death (GO:0012501)
Children of cornification (GO:0070268)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of cornification (GO:1905715) [RO:0002211 relation] RO:0002211  cornification
positive regulation of cornification (GO:1905717) [RO:0002213 relation] RO:0002213  cornification
negative regulation of cornification (GO:1905716) [RO:0002212 relation] RO:0002212  cornification
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