Term Information

Data health 
Accession
GO:0097191
Name
extrinsic apoptotic signaling pathway
Ontology
biological_process
Synonyms
extrinsic apoptotic pathway, extrinsic apoptotic signalling pathway, death receptor-mediated apoptosis, extrinsic apoptosis, extrinsic apoptotic signaling pathway in presence of ligand
Alternate IDs
None
Definition
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. Source: GOC:yaf, GOC:mtg_apoptosis, PMID:17340152
Comment
Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
History
See term history for GO:0097191 at QuickGO
Subset
None

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Parents of extrinsic apoptotic signaling pathway (GO:0097191)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
extrinsic apoptotic signaling pathway [is_a relation] is_a  apoptotic signaling pathway (GO:0097190)
extrinsic apoptotic signaling pathway [is_a relation] is_a  cell surface receptor signaling pathway (GO:0007166)
Children of extrinsic apoptotic signaling pathway (GO:0097191)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ripoptosome assembly involved in extrinsic apoptotic signaling pathway (GO:1901025) [BFO:0000050 relation] BFO:0000050  extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway (GO:2001238) [RO:0002213 relation] RO:0002213  extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway (GO:2001236) [RO:0002211 relation] RO:0002211  extrinsic apoptotic signaling pathway
ovarian follicle atresia (GO:0001552) [BFO:0000051 relation] BFO:0000051  extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237) [RO:0002212 relation] RO:0002212  extrinsic apoptotic signaling pathway
B cell receptor apoptotic signaling pathway (GO:1990117) [is_a relation] is_a  extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625) [is_a relation] is_a  extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192) [is_a relation] is_a  extrinsic apoptotic signaling pathway
death-inducing signaling complex assembly (GO:0071550) [BFO:0000050 relation] BFO:0000050  extrinsic apoptotic signaling pathway
fibroblast growth factor receptor apoptotic signaling pathway (GO:1902178) [is_a relation] is_a  extrinsic apoptotic signaling pathway
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