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Available structures
PDBOrtholog search: PDBe RCSB
AliasesCD180, LY64, Ly78, RP105, CD180 molecule
External IDsOMIM: 602226 MGI: 1194924 HomoloGene: 4077 GeneCards: CD180
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CD180
Genomic location for CD180
Band5q12.3Start67,179,613 bp[1]
End67,196,799 bp[1]
RNA expression pattern
PBB GE CD180 206206 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 5: 67.18 – 67.2 MbChr 13: 102.69 – 102.74 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

CD180 antigen is a protein that in humans is encoded by the CD180 gene.[5][6][7][8]

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.[7]

Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia.[9][10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134061 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021624 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–22. PMID 9763566.
  6. ^ Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID 8975706.
  7. ^ a b "Entrez Gene: CD180 CD180 molecule".
  8. ^ [permanent dead link] [4]
  9. ^ Porakishvili, Nino; Memon, Azka; Vispute, Ketki; Kulikova, Nina; Clark, Edward A.; Rai, Kanti R.; Nathwani, Amit; Damle, Rajendra N.; Chiorazzi, Nicholas; Lydyard, Peter M. (May 2011). "CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells". British Journal of Haematology. 153 (4): 486–498. doi:10.1111/j.1365-2141.2011.08605.x. ISSN 0007-1048.
  10. ^ Gordiienko, Inna; Shlapatska, Larysa; Kholodniuk, Valeriia; Sklyarenko, Lilia; Gluzman, Daniel F.; Clark, Edward A.; Sidorenko, Svetlana P. (2017-10-05). "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling". PLOS ONE. 12 (10): e0185940. doi:10.1371/journal.pone.0185940. ISSN 1932-6203. PMC 5628907. PMID 28982149.

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