KLF13

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KLF13
Identifiers
AliasesKLF13, BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1, Kruppel-like factor 13, Kruppel like factor 13
External IDsOMIM: 605328 MGI: 1354948 HomoloGene: 32288 GeneCards: KLF13
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for KLF13
Genomic location for KLF13
Band15q13.3Start31,326,835 bp[1]
End31,435,665 bp[1]
RNA expression pattern
PBB GE KLF13 219878 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001302461
NM_015995

NM_021366

RefSeq (protein)

NP_001289390
NP_057079

NP_067341

Location (UCSC)Chr 15: 31.33 – 31.44 MbChr 7: 63.89 – 63.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.[5][6][7]

There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes.[8] Ghrelin levels also positively correlated with methylation levels of cg07814318.[8] Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.[8]

Function[edit]

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[5][9]

KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[7] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[7][10][11][12][13][14][15]

Interactions[edit]

KLF13 has been shown to interact with CREB-binding protein,[16] Heat shock protein 47[16] and PCAF.[16]

See also[edit]

References[edit]

  1. ^ a b c ENSG00000275746 GRCh38: Ensembl release 89: ENSG00000169926, ENSG00000275746 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052040 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: KLF13 Kruppel-like factor 13".
  6. ^ Cook T, Gebelein B, Urrutia R (Jun 1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences. 880 (1 CELL AND MOLE): 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.
  7. ^ a b c Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (Jan 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity. 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
  8. ^ a b c Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB (14 Feb 2017). "A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels". Int J Obes (Lond). 43 (6): 990–994. doi:10.1038/ijo.2017.43. PMID 28194012.
  9. ^ Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics. 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.
  10. ^ Song A, Nikolcheva T, Krensky AM (Oct 2000). "Transcriptional regulation of RANTES expression in T lymphocytes". Immunological Reviews. 177 (1): 236–45. doi:10.1034/j.1600-065X.2000.17610.x. PMID 11138780.
  11. ^ Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM (Jul 2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". The Journal of Clinical Investigation. 110 (1): 119–26. doi:10.1172/JCI15336. PMC 151028. PMID 12093895.
  12. ^ Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM (Aug 2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". The Journal of Biological Chemistry. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.
  13. ^ Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM (May 2007). "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". Journal of Immunology. 178 (9): 5496–504. doi:10.4049/jimmunol.178.9.5496. PMC 2664650. PMID 17442931.
  14. ^ Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM (Jun 2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC 2674583. PMID 17513757.
  15. ^ Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM (Jan 2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Molecular and Cellular Biology. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMC 1800668. PMID 17074812.
  16. ^ a b c Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G (Mar 2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry. 277 (9): 7029–36. doi:10.1074/jbc.M108826200. PMC 2808425. PMID 11748222.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.