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Protein TEAD3 PDB 2hzd.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesTEAD3, DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5, TEA domain transcription factor 3
External IDsOMIM: 603170 MGI: 109241 HomoloGene: 81821 GeneCards: TEAD3
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TEAD3
Genomic location for TEAD3
Band6p21.31Start35,473,597 bp[1]
End35,497,079 bp[1]
RNA expression pattern
PBB GE TEAD3 209454 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 35.47 – 35.5 MbChr 17: 28.33 – 28.35 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.[5][6][7]


This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[8] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.[9] Translation of this protein is initiated at a non-AUG (AUA) start codon.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007866 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002249 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.
  6. ^ Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry. 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898.
  7. ^ a b "Entrez Gene: TEAD3 TEA domain family member 3".
  8. ^ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell. 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413.
  9. ^ Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns. 7 (8): 827–36. doi:10.1016/j.modgep.2007.08.001. PMC 3360971. PMID 17916448.

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