1821 in the United States
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Events from the year 1821 in the United States.
- President: James Monroe (DR-Virginia)
- Vice President: Daniel D. Tompkins (DR-New York)
- Chief Justice: John Marshall (Virginia)
- Speaker of the House of Representatives: John W. Taylor (DR-New York) (until March 4), Philip Pendleton Barbour (DR-Virginia) (starting December 4)
- Congress: 16th (until March 4), 17th (starting March 4)
- February 9 – The George Washington University is chartered as The Columbian College of the District of Columbia by President James Monroe.
- March 5 – James Monroe is sworn in for his second term as President of the United States.
- June 27 – The New Hampton School is founded in the state of New Hampshire.
- July 10 – The U.S. takes possession of its newly bought territory of Florida from Spain.
- August 4 – The Saturday Evening Post relaunched.
- August 10 – Missouri is admitted as the 24th U.S. state (see History of Missouri).
- September 3 – The 1821 Norfolk and Long Island hurricane strikes New York City.
- September 18 – Amherst College is founded in Massachusetts.
- November 16 – American Old West: The Santa Fe Trail is used by the first White American.
- History of Liberia – The first groups of freed slaves from the U.S. arrive in modern-day Liberia and found Monrovia.
- Era of Good Feelings (1817–1825)
- January 2 – Napoleon LeBrun, architect (died 1901)
- January 8 – James Longstreet, one of the foremost Confederate generals of the American Civil War (died 1904)
- January 16 – John C. Breckinridge, 14th Vice President of the United States from 1857 to 1861, U.S. Senator from Kentucky in 1861 (died 1875)
- February 4 – Frederick Goddard Tuckerman, sonneteer (died 1873)
- February 19 – Francis Preston Blair Jr., U.S. Senator from Missouri from 1871 to 1873 (died 1875)
- March 20 – Ned Buntline (Edward Zane Carroll Judson Sr.), publisher, dime novelist and publicist (died 1886)
- April 12
- April 15 – Joseph E. Brown, U.S. Senator from Georgia from 1880 to 1891 (died 1894)
- July 6 – Edmund Pettus, U.S. Senator from Alabama from 1897 to 1907 (died 1907)
- July 8 – Maria White Lowell, poet and abolitionist (died 1853)
- July 13 – Nathan Bedford Forrest, Confederate Civil War General, first Grand Wizard of the Ku Klux Klan (died 1877)
- September 22 – John Conness, Irish-born U.S. Senator from California from 1863 to 1869 (died 1909)
- October 7 – Richard H. Anderson, United States Army officer during the Mexican–American War, Confederate general during the American Civil War (died 1879)
- October 10 – Wade Keyes, Acting Confederate States Attorney General in 1861 and 1863–1864 (died 1879)
- October 22 – Collis P. Huntington, railroad promoter (died 1900)
- December 25 – Clara Barton, humanitarian and founder of the American branch of the Red Cross.
- January 4 – Elizabeth Ann Seton, saint (born 1774)
- March 13 – Waightstill Avery, lawyer and soldier, fought a duel with Andrew Jackson (born 1741)
- October 11 – John Ross Key, commissioned officer in the Continental Army, judge, lawyer and father of Francis Scott Key (born 1754)
- October 24 – Elias Boudinot, President of the Continental Congress (born 1740)
- Full Date Unknown – Lucy Terry first known African American poet (born c. 1730 in Africa)
- Media related to 1821 in the United States at Wikimedia Commons