The 1888 United States presidential election in Colorado took place on November 6, 1888, as part of the 1888 United States presidential election. Voters chose three representatives, or electors to the Electoral College, who voted for president and vice president.
Colorado voted for the Republican nominee, Benjamin Harrison, over the Democratic nominee, incumbent President Grover Cleveland. Harrison won the state by a margin of 14.38 percent.
With 55.22% of the popular vote, Colorado would prove to be Harrison's fifth strongest victory in terms of percentage in the popular vote after Vermont, Nevada, Maine and Kansas.