The 1926 United States Senate elections in Arizona took place on November 3, 1926. Incumbent Republican U.S. Senator Ralph H. Cameron ran for reelection to a second term, but was defeated by U.S. Congressman Carl T. Hayden in the general election.
Cameron received the support of Republican leaders but only tepid support from rank and file membership. In contrast, his challenger, Congressman Carl Hayden, in turn had a united party, the backing of labor, and the support of the Woman's Christian Temperance Union. Cameron campaigned on a message highlighting his successes during his first term. Democrats countered by highlighting his inability to win a cotton tariff, showing him to be ineffective.
A series of six article written by Hayden supporter Will Irwin was published by the Los Angeles Times in mid-1926. These articles examined Cameron's history with the Grand Canyon and claimed he had salted several claims in the canyon in order to control the valuable sites. Cameron condemned the articles' claims as "malicious fabrications" but the political damage had already been done. Hayden won the election by a vote of 44,591 to 31,845.