The 1976 Major League Baseball season was the last post 1961-season until 1993 in which the American League (AL) and the National League (NL) had the same number of teams. The season ended with the Cincinnati Reds taking the World Series Championship for the second consecutive season by sweeping the New York Yankees in four games. It would be the Reds' last title until Lou Piniella guided the club in 1990, and the second time that the Yankees were swept in World Series history. The only team to do it before was the 1963 Los Angeles Dodgers.
July 26 – Carl Yastrzemski of the Boston Red Sox gets his 2500th hit versus the Cleveland Indians, a double in the 1st off of Stan Thomas at Fenway Park. The Red Sox lost 9-4. Yastrzemski was beaten to the milestone one week earlier by his contemporary, Willie Davis on July 19.
August 8 – The first game of today's Royals–White Sox double header at Comiskey Park sees the White Sox appear on the field in shorts. The Sox return to long pants for the second game, after stealing five bases and defeating the Royals, 5-2.
September 3 – At Shea Stadium, Tom Seaver fans Tommy Hutton of the Phillies in the 7th inning of the Mets 1-0 victory. Hutton is Seaver's 200th strikeout victim of the season – the 9th straight year the Mets' right-hander has reached that mark.
September 6 – Dodgers catcher Steve Yeager is seriously injured when the jagged end of a broken bat strikes him in the throat while he is waiting in the on-deck circle.
September 10 – California's Nolan Ryan strikes out 18 White Sox hitters in a 9-inning 3-2 victory at Chicago.
September 11 – Orestes "Minnie" Miñoso comes out of his twelve-year retirement. Playing at home for the White Sox, he goes 0-for-3 against Frank Tanana. The next day, he will single, becoming the oldest player to hit safely in a Major League game.
September 18 – Player-Manager Frank Robinson of the Cleveland Indians inserts himself into the lineup as a pinch hitter in the eight inning of a game against the Baltimore Orioles. He singles in what will be his final at-bat as a player. His influence as a manager and executive will continue for decades to come.
September 21 – In Los Angeles, the Cincinnati Reds clinch the National League West title with a 9-1 pasting of the Dodgers.
September 25 – The Yankees put an end to a 6-game losing streak with a 10-6 win over the Tigers to wrap up the Al East, the Yankees' first visit to the postseason since the 1964 World Series. Doyle Alexander gets the victory.
September 26 – In the last big league games at Montreal's Jarry Park, the Philadelphia Phillies beat the Montreal Expos 4-1 in the first game of a doubleheader to clinch the National League East title. Philly takes the nightcap, 2-1. Following the 2nd game, Dick Allen jumps the team in protest of the fact that veteran Tony Taylor is not listed on the post-season roster.
September 28 – The Dodgers' Walter Alston, after 23 seasons and 2,040 victories, steps down as manager. Third base coach Tommy Lasorda is promoted to the post.