From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
ABT-670 structure.png
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass325.404 g/mol g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

ABT-670 is a drug which acts as a potent, orally bioavailable dopamine agonist selective for the D4 subtype, which was developed as a possible treatment for erectile dysfunction,[1] although its current uses are limited to scientific research.[2]

See also[edit]


  1. ^ Patel, M. V.; Kolasa, T.; Mortell, K.; Matulenko, M. A.; Hakeem, A. A.; Rohde, J. J.; Nelson, S. L.; Cowart, M. D.; Nakane, M.; Miller, L. N.; Uchic, M. E.; Terranova, M. A.; El-Kouhen, O. F.; Donnelly-Roberts, D. L.; Namovic, M. T.; Hollingsworth, P. R.; Chang, R.; Martino, B. R.; Wetter, J. M.; Marsh, K. C.; Martin, R.; Darbyshire, J. F.; Gintant, G.; Hsieh, G. C.; Moreland, R. B.; Sullivan, J. P.; Brioni, J. D.; Stewart, A. O. (2006). "Discovery of 3-Methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-\2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an Orally Bioavailable Dopamine D4Agonist for the Treatment of Erectile Dysfunction". Journal of Medicinal Chemistry. 49 (25): 7450–7465. doi:10.1021/jm060662k. PMID 17149874.
  2. ^ Richards N, Wayman C, Allers KA. Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection. Neuroscience Letters. 3 September 2009 doi:10.1016/j.neulet.2009.08.078