ACTR2

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ACTR2
Protein ACTR2 PDB 1k8k.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACTR2, ARP2, ARP2 actin-related protein 2 homolog (yeast), ARP2 actin related protein 2 homolog, actin related protein 2
External IDsOMIM: 604221 MGI: 1913963 HomoloGene: 4181 GeneCards: ACTR2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ACTR2
Genomic location for ACTR2
Band2p14Start65,227,753 bp[1]
End65,271,253 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005722
NM_001005386

NM_146243
NM_001362899

RefSeq (protein)

NP_001005386
NP_005713

NP_666355
NP_001349828

Location (UCSC)Chr 2: 65.23 – 65.27 MbChr 11: 20.06 – 20.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin-related protein 2 is a protein that in humans is encoded by the ACTR2 gene.[5]

The specific function of ACTR2 has not yet been determined. However, it is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138071 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020152 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
  6. ^ "Entrez Gene: ACTR2 ARP2 actin-related protein 2 homolog (yeast)".

Further reading[edit]

External links[edit]