ACTR3

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ACTR3
Protein ACTR3 PDB 1k8k.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACTR3, ARP3, ARP3 actin-related protein 3 homolog (yeast), ARP3 actin related protein 3 homolog, actin related protein 3
External IDsOMIM: 604222 MGI: 1921367 HomoloGene: 68483 GeneCards: ACTR3
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ACTR3
Genomic location for ACTR3
Band2q14.1Start113,890,063 bp[1]
End113,962,596 bp[1]
RNA expression pattern
PBB GE ACTR3 200996 at fs.png

PBB GE ACTR3 213102 at fs.png

PBB GE ACTR3 213101 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001277140
NM_005721

NM_001205385
NM_001205386
NM_023735

RefSeq (protein)

NP_001264069
NP_005712

NP_001192314
NP_001192315
NP_076224

Location (UCSC)Chr 2: 113.89 – 113.96 MbChr 1: 125.39 – 125.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene.[5]

Function[edit]

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.[6]

Interactions[edit]

ACTR3 has been shown to interact with Cortactin.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115091 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026341 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Jul 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". The Journal of Cell Biology. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
  6. ^ "Entrez Gene: ACTR3 ARP3 actin-related protein 3 homolog (yeast)".
  7. ^ Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT (Oct 2000). "Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex". The Journal of Cell Biology. 151 (1): 29–40. doi:10.1083/jcb.151.1.29. PMC 2189811. PMID 11018051.
  8. ^ Di Ciano C, Nie Z, Szászi K, Lewis A, Uruno T, Zhan X, Rotstein OD, Mak A, Kapus A (Sep 2002). "Osmotic stress-induced remodeling of the cortical cytoskeleton". American Journal of Physiology. Cell Physiology. 283 (3): C850–65. doi:10.1152/ajpcell.00018.2002. PMID 12176742.

Further reading[edit]

External links[edit]