ACYP2

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ACYP2
Protein ACYP2 PDB 1aps.png
Identifiers
AliasesACYP2, ACYM, ACYP, acylphosphatase 2
External IDsOMIM: 102595 MGI: 1922822 HomoloGene: 41776 GeneCards: ACYP2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ACYP2
Genomic location for ACYP2
Band2p16.2Start53,970,838 bp[1]
End54,305,300 bp[1]
RNA expression pattern
PBB GE ACYP2 gnf1h09944 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_029344

RefSeq (protein)

NP_083620

Location (UCSC)Chr 2: 53.97 – 54.31 MbChr 11: 30.51 – 30.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acylphosphatase-2 is an enzyme that in humans is encoded by the ACYP2 gene.[5][6]

Function[edit]

Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170634 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060923 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Modesti A, Raugei G, Taddei N, Marzocchini R, Vecchi M, Camici G, Manao G, Ramponi G (Dec 1993). "Chemical synthesis and expression of a gene coding for human muscle acylphosphatase". Biochimica et Biophysica Acta. 1216 (3): 369–74. doi:10.1016/0167-4781(93)90003-v. PMID 8268218.
  6. ^ a b "Entrez Gene: ACYP2 acylphosphatase 2, muscle type".

External links[edit]

Further reading[edit]