AKR7A2

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AKR7A2
Protein AKR7A2 PDB 2bp1.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7, aldo-keto reductase family 7, member A2, aldo-keto reductase family 7 member A2
External IDsOMIM: 603418 MGI: 107796 HomoloGene: 2737 GeneCards: AKR7A2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for AKR7A2
Genomic location for AKR7A2
Band1p36.13Start19,303,965 bp[1]
End19,312,146 bp[1]
RNA expression pattern
PBB GE AKR7A2 214259 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003689
NM_001320979

NM_025337

RefSeq (protein)

NP_001307908
NP_003680

NP_079613

Location (UCSC)Chr 1: 19.3 – 19.31 MbChr 4: 139.31 – 139.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene.[5][6]

Function[edit]

Aldo-keto reductases, such as AKR7A2, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM][6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000053371 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028743 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ireland LS, Harrison DJ, Neal GE, Hayes JD (Aug 1998). "Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase". Biochem J. 332 (1): 21–34. doi:10.1042/bj3320021. PMC 1219447. PMID 9576847.
  6. ^ a b "Entrez Gene: AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)".

External links[edit]

  • Human AKR7A2 genome location and AKR7A2 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)

Further reading[edit]