ALS2CR8

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CARF
Identifiers
AliasesCARF, ALS2CR8, NYD-SP24, calcium responsive transcription factor
External IDsOMIM: 607586 MGI: 2182269 HomoloGene: 11689 GeneCards: CARF
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CARF
Genomic location for CARF
Band2q33.2Start202,912,214 bp[1]
End202,988,263 bp[1]
RNA expression pattern
PBB GE ALS2CR8 219834 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001285463
NM_001285473
NM_139150

RefSeq (protein)

NP_001272392
NP_001272402
NP_631889

Location (UCSC)Chr 2: 202.91 – 202.99 MbChr 1: 60.1 – 60.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein also known as calcium-response factor (CaRF) is a protein that in humans is encoded by the ALS2CR8 gene.[5][6]

Knocking out the Carf (Als2cr8) gene in mice results in learning associated deficits. Furthermore, Carf has been shown to function as a transcription factor that regulates the expression of BDNF.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138380 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026017 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298.
  6. ^ "Entrez Gene: ALS2CR8 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8".
  7. ^ Tao X, West AE, Chen WG, Corfas G, Greenberg ME (January 2002). "A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF". Neuron. 33 (3): 383–95. doi:10.1016/S0896-6273(01)00561-X. PMID 11832226.

External links[edit]

Further reading[edit]