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AliasesATF5, ATFX, HMFN0395, activating transcription factor 5
External IDsOMIM: 606398 MGI: 2141857 HomoloGene: 32142 GeneCards: ATF5
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ATF5
Genomic location for ATF5
Band19q13.33Start49,928,702 bp[1]
End49,933,935 bp[1]
RNA expression pattern
PBB GE ATF5 204998 s at fs.png

PBB GE ATF5 204999 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 49.93 – 49.93 MbChr 7: 44.81 – 44.82 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.[5]


First described by Nishizawa and Nagata,[6] ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.[7][8]

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at both the transcriptional and translational level.

ATF5 is expressed in VZ and SVZ during brain development.

The human ATF5 protein is made up of 282 amino acids.

ATF5 is a transcription factor that contains a bZip domain.

See also[edit]


ATF5 has been shown to interact with DISC1[9] and TRIB3.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169136 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038539 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: ATF5 activating transcription factor 5".
  6. ^ Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
  7. ^ Hai T, Hartman MG (July 2001). "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene. 273 (1): 1–11. doi:10.1016/S0378-1119(01)00551-0. PMID 11483355.
  8. ^ Vinson C, Myakishev M, Acharya A, Mir AA, Moll JR, Bonovich M (September 2002). "Classification of human B-ZIP proteins based on dimerization properties". Mol. Cell. Biol. 22 (18): 6321–6335. doi:10.1128/MCB.22.18.6321-6335.2002. PMC 135624. PMID 12192032.
  9. ^ Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. doi:10.1093/hmg/ddg162. PMID 12812986.
  10. ^ Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–948. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.