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Acanthosis nigricans

Acanthosis is diffuse epidermal hyperplasia (thickening of the skin).[1] It implies increased thickness of the Malpighian layer (stratum basale and stratum spinosum).[2]

Acanthosis nigricans is often associated with type 2 diabetes, and is usually observed in the back of neck, axilla, and other folded regions of the skin. However, acanthosis nigricans can also be associated with other conditions such as niacin toxicity.

See also[edit]


  1. ^ Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
  2. ^ M. S. Stone; T. L. Ray (September 1995). "Acanthosis". DermPathTutor. Department of Dermatology, University of Iowa. Archived from the original on 29 May 2012. Retrieved 17 May 2012.