|Synonyms||W-2965-A; 5-Acetyltryptamine; 5-Acetyl-3-(2-aminoethyl)indole;|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||202.257 g/mol g·mol−1|
|3D model (JSmol)|
Acetryptine (INN) (developmental code name W-2965-A), also known as 5-acetyltryptamine (5-AT), is a drug described as an antihypertensive agent which was never marketed. Structurally, acetryptine is a substituted tryptamine, and is closely related to other substituted tryptamines like serotonin (5-hydroxytryptamine). It was developed in the early 1960s. The binding of acetryptine to serotonin receptors does not seem to have been well-investigated, although it was assessed at the 5-HT1A and 5-HT1D receptors and found to bind to them with high affinity. The drug may also act as a monoamine oxidase inhibitor (MAOI); specifically, as an inhibitor of MAO-A.
- HARTIGAN JM, PHILLIPS GE (1963). "Tissue distribution and metabolism of 5-acetyltryptamine in the mouse". Biochem. Pharmacol. 12: 585–8. doi:10.1016/0006-2952(63)90136-9. PMID 13953098.
- J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 6–. ISBN 978-1-4757-2085-3.
- Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C (1996). "Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors". J. Med. Chem. 39 (1): 314–22. doi:10.1021/jm950498t. PMID 8568822.
- Veselovsky AV, Medvedev AE, Tikhonova OV, Skvortsov VS, Ivanov AS (2000). "Modeling of substrate-binding region of the active site of monoamine oxidase A". Biochemistry Mosc. 65 (8): 910–6. PMID 11002183.
- Ramsay RR, Gravestock MB (2003). "Monoamine oxidases: to inhibit or not to inhibit". Mini Rev Med Chem. 3 (2): 129–36. doi:10.2174/1389557033405287. PMID 12570845.
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