Agouti-signaling protein

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesASIP, AGSW, AGTI, AGTIL, ASP, SHEP9, agouti signaling protein
External IDsOMIM: 600201 MGI: 87853 HomoloGene: 1264 GeneCards: ASIP
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ASIP
Genomic location for ASIP
Band20q11.22Start34,194,569 bp[1]
End34,269,344 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 20: 34.19 – 34.27 Mbn/a
PubMed search[2][3]
View/Edit HumanView/Edit Mouse

Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene.[4][5]

Agouti signalling peptide is a peptide consisting of 131 amino acids. Its discovery was published in 1994 in the scientific journal Nature where its functional properties were described. It acts as an inverse agonist at melanocortin receptors.[6]


In mice, the agouti gene encodes a paracrine signalling molecule that causes hair follicle melanocytes to synthesize the yellow pigment pheomelanin instead of the black or brown pigment eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as an inverse agonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.[7]


NMR structure family of Agouti Signalling Protein, C-terminal knotting domain. PDB entry 1y7k[8]

Agouti signalling peptide adopts an inhibitor cystine knot motif.[8] Along with the homologous Agouti-related peptide, these are the only known mammalian proteins to adopt this fold.

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101440 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Kwon HY, Bultman SJ, Löffler C, Chen WJ, Furdon PJ, Powell JG, Usala AL, Wilkison W, Hansmann I, Woychik RP (October 1994). "Molecular structure and chromosomal mapping of the human homolog of the agouti gene". Proceedings of the National Academy of Sciences of the United States of America. 91 (21): 9760–4. Bibcode:1994PNAS...91.9760K. doi:10.1073/pnas.91.21.9760. PMC 44896. PMID 7937887.
  5. ^ Wilson BD, Ollmann MM, Kang L, Stoffel M, Bell GI, Barsh GS (February 1995). "Structure and function of ASP, the human homolog of the mouse agouti gene". Human Molecular Genetics. 4 (2): 223–30. doi:10.1093/hmg/4.2.223. PMID 7757071.
  6. ^ Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, Luther M, Chen W, Woychik RP, Wilkison WO (October 1994). "Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor". Nature. 371 (6500): 799–802. Bibcode:1994Natur.371..799L. doi:10.1038/371799a0. PMID 7935841.
  7. ^ "Entrez Gene: ASIP".
  8. ^ a b McNulty JC, Jackson PJ, Thompson DA, Chai B, Gantz I, Barsh GS, Dawson PE, Millhauser GL (2005). "Structures of the agouti signaling protein". Journal of Molecular Biology. 346 (4): 1059–1070. doi:10.1016/j.jmb.2004.12.030. PMID 15701517.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.