ANGPT4

From Wikipedia, the free encyclopedia
  (Redirected from Angiopoietin 4)
Jump to navigation Jump to search
ANGPT4
Identifiers
AliasesANGPT4, AGP4, ANG-3, ANG4, ANG3, angiopoietin 4
External IDsOMIM: 603705 MGI: 1336887 HomoloGene: 36302 GeneCards: ANGPT4
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ANGPT4
Genomic location for ANGPT4
Band20p13Start869,900 bp[1]
End916,334 bp[1]
RNA expression pattern
PBB GE ANGPT4 221134 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015985
NM_001322809

NM_009641

RefSeq (protein)

NP_001309738
NP_057069

NP_033771

Location (UCSC)Chr 20: 0.87 – 0.92 MbChr 2: 151.91 – 151.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.[5][6][7]

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells.

The protein encoded by this gene functions as an agonist and is an angiopoietin.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101280 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027460 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (Apr 1999). "Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans". Proc Natl Acad Sci U S A. 96 (5): 1904–9. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.
  6. ^ Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S (May 1999). "Angiopoietin-3, a novel member of the angiopoietin family". FEBS Lett. 448 (2–3): 254–6. doi:10.1016/S0014-5793(99)00381-6. PMID 10218486.
  7. ^ a b "Entrez Gene: ANGPT4 angiopoietin 4".

External links[edit]

Further reading[edit]