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AliasesBHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14, basic helix-loop-helix family member e40, Clast5, SHARP2
External IDsMGI: 1097714 HomoloGene: 2722 GeneCards: BHLHE40
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for BHLHE40
Genomic location for BHLHE40
Band3p26.1Start4,979,116 bp[1]
End4,985,323 bp[1]
RNA expression pattern
PBB GE BHLHB2 201169 s at fs.png

PBB GE BHLHB2 201170 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 4.98 – 4.99 MbChr 6: 108.66 – 108.67 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.[5][6][7][8]


DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134107 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030103 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M, Kato Y (Jul 1997). "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes". Biochemical and Biophysical Research Communications. 236 (2): 294–8. doi:10.1006/bbrc.1997.6960. PMID 9240428.
  6. ^ Antonevich T, Taneja R (Oct 1999). "Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 254–5. doi:10.1159/000015305. PMID 10449910.
  7. ^ Stevens JD, Roalson EH, Skinner MK (Nov 2008). "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation; Research in Biological Diversity. 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMC 5728086. PMID 18557763.
  8. ^ a b "Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.