BMX (gene)

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Protein BMX PDB 2EKX.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesBMX, ETK, PSCTK2, PSCTK3, BMX non-receptor tyrosine kinase
External IDsOMIM: 300101 MGI: 1101778 HomoloGene: 20411 GeneCards: BMX
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for BMX
Genomic location for BMX
BandXp22.2Start15,464,246 bp[1]
End15,556,529 bp[1]
RNA expression pattern
PBB GE BMX 206464 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 15.46 – 15.56 MbChr X: 164.19 – 164.26 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.[5][6]


Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC, TXK, ITK, and BTK. All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.[6]


BMX has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102010 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031377 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tamagnone L, Lahtinen I, Mustonen T, Virtaneva K, Francis F, Muscatelli F, Alitalo R, Smith CI, Larsson C, Alitalo K (December 1994). "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2". Oncogene. 9 (12): 3683–8. PMID 7970727.
  6. ^ a b "Entrez Gene: BMX BMX non-receptor tyrosine kinase".
  7. ^ Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, Kumar R (August 2001). "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. doi:10.1074/jbc.M103129200. PMID 11382770.
  8. ^ Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y, Qiu Y (May 2001). "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. doi:10.1038/35074500. PMID 11331870.
  9. ^ Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM (December 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.
  10. ^ Yang J, Kim O, Wu J, Qiu Y (August 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.

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