BST1

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BST1
Protein BST1 PDB 1isf.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBST1, CD157, bone marrow stromal cell antigen 1
External IDsOMIM: 600387 MGI: 105370 HomoloGene: 3198 GeneCards: BST1
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for BST1
Genomic location for BST1
Band4p15.32Start15,703,065 bp[1]
End15,738,313 bp[1]
RNA expression pattern
PBB GE BST1 205715 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004334

NM_009763

RefSeq (protein)

NP_004325

NP_033893

Location (UCSC)Chr 4: 15.7 – 15.74 MbChr 5: 43.82 – 43.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosyl cyclase 2 is an enzyme that in humans is encoded by the BST1 gene.[5][6]

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109743 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029082 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kaisho T, Ishikawa J, Oritani K, Inazawa J, Tomizawa H, Muraoka O, Ochi T, Hirano T (Jul 1994). "BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth". Proc Natl Acad Sci U S A. 91 (12): 5325–9. doi:10.1073/pnas.91.12.5325. PMC 43987. PMID 8202488.
  6. ^ a b "Entrez Gene: BST1 bone marrow stromal cell antigen 1".

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.