3D model (JSmol)
|Molar mass||356.301 g·mol−1|
|Solubility in other solvents||DMSO: 184 mg/mL; methanol and ethanol: 63 mg/mL|
|S-phrases (outdated)||S26 S36|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Bay K8644 is a chemical compound that functions as a calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect. It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.
Mechanism of action
Bay K8644 targets voltage-sensitive dihydropyridine (DHP) calcium channels (L-Type). It is the first positive inotropic agent shown to act specifically and directly on calcium channels.
- (±)-Bay K8644 at Sigma-Aldrich
- CID 2303 from PubChem
- Thomas, G; Chung, M; Cohen, CJ (January 1985). "A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent". Circ Res. 56 (1): 87–96. doi:10.1161/01.res.56.1.87. PMID 2578336.
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