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Bupropion and zonisamide.svg
Combination of
BupropionNorepinephrine-dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist
ZonisamideSulfonamide anticonvulsant
Legal status
Legal status
  • Investigational

Bupropion/zonisamide (planned trade name Empatic) is an experimental drug combination for the treatment of obesity.[1] It is being developed by Orexigen Therapeutics. It is currently at phase II testing.[2][3] The combination consists of two prescription medications approved by the U.S. Food and Drug Administration (FDA) for other ailments.[4] When mixed together and tested along with proper diet and moderate exercise, they produced a substantial weight loss effect higher than the group taking a placebo.

Empatic was called Excalia before its name was changed.[5]

See also[edit]


  1. ^ Empatic Shows Long-Term Weight Loss, Improved Quality Of Life Contrave(R) Reduces Rate Of Metabolic Syndrome By Half
  2. ^ Ioannides-Demos, LL; Piccenna, L; McNeil, JJ (2011). "Pharmacotherapies for obesity: past, current, and future therapies" (PDF). Journal of Obesity. 2011: 179674. doi:10.1155/2011/179674. PMC 3006492. PMID 21197148.
  3. ^ Adan, RAH (February 2013). "Mechanisms underlying current and future anti-obesity drugs". Trends in Neurosciences. 36 (2): 133–140. doi:10.1016/j.tins.2012.12.001. PMID 23312373.
  4. ^ Orexigen says trial of 2nd obesity drug meets goal
  5. ^ Empatic Obesity Drug Information and News