This protein belongs to family A of G protein-coupled receptor superfamily. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
CCR6 has been associated with Crohn's disease.
Expression of CCR6 was found to be up-regulated in colorectal cancer. Novel research has identified a microRNA that is able to downregulate CCR6 in cancer cell lines.
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