Integrin alpha X

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ITGAX
Protein ITGAX PDB 1n3y.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITGAX, CD11C, SLEB6, integrin subunit alpha X
External IDsOMIM: 151510 MGI: 96609 HomoloGene: 55493 GeneCards: ITGAX
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for ITGAX
Genomic location for ITGAX
Band16p11.2Start31,355,134 bp[1]
End31,382,997 bp[1]
RNA expression pattern
PBB GE ITGAX 210184 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000887
NM_001286375

NM_021334
NM_001363984
NM_001363985

RefSeq (protein)

NP_000878
NP_001273304

NP_067309
NP_001350913
NP_001350914

Location (UCSC)Chr 16: 31.36 – 31.38 MbChr 7: 128.13 – 128.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .[5][6]

CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[5]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140678 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030789 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)".
  6. ^ Dyer KD, Garcia-Crespo KE, Killoran KE, Rosenberg HF (2011). "Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometry". Journal of Immunological Methods. 369 (1–2): 91–7. doi:10.1016/j.jim.2011.04.009. PMC 3116057. PMID 21565196.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.