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AliasesCD248, CD164L1, TEM1, CD248 molecule
External IDsOMIM: 606064 MGI: 1917695 HomoloGene: 10699 GeneCards: CD248
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CD248
Genomic location for CD248
Band11q13.2Start66,314,494 bp[1]
End66,317,044 bp[1]
RNA expression pattern
PBB GE CD248 219025 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 11: 66.31 – 66.32 MbChr 19: 5.07 – 5.07 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Endosialin is a protein that in humans is encoded by the CD248 gene.[5][6][7]

Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise two other members, CD93 and Thrombomodulin which are better characterized.

The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth.[8]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174807 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056481 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988.
  6. ^ Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC (May 2001). "Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium". J Biol Chem. 276 (10): 7408–14. doi:10.1074/jbc.M009604200. PMID 11084048.
  7. ^ "Entrez Gene: CD248 CD248 molecule, endosialin".
  8. ^ Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P (2006). "Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis". Cancer Immun. 6: 10. PMID 16875435.

Further reading[edit]

External links[edit]