T-cell surface glycoprotein CD3 epsilon chain

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CD3E
Protein CD3E PDB 1xiw.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD3E, IMD18, T3E, TCRE, CD3e molecule
External IDsOMIM: 186830 MGI: 88332 HomoloGene: 586 GeneCards: CD3E
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CD3E
Genomic location for CD3E
Band11q23.3Start118,304,545 bp[1]
End118,316,175 bp[1]
RNA expression pattern
PBB GE CD3E 205456 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000733

NM_007648

RefSeq (protein)

NP_000724

NP_031674

Location (UCSC)Chr 11: 118.3 – 118.32 MbChr 9: 45 – 45.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.[5][6]

Function[edit]

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.[7]

Clinical significance[edit]

Defects in this gene cause severe immunodeficiency.[8][9] This gene has also been linked to a susceptibility to type I diabetes in women.[10]

Interactions[edit]

T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B,[11] CD3EAP[12] and NCK2.[13]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198851 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032093 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature. 321 (6068): 431–4. doi:10.1038/321431a0. PMID 3012357.
  6. ^ Clevers HC, Dunlap S, Wileman TE, Terhorst C (November 1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235.
  7. ^ "Entrez Gene: CD3E CD3e molecule, epsilon (CD3-TCR complex)".
  8. ^ Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B (January 1993). "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency". Nature Genetics. 3 (1): 77–81. doi:10.1038/ng0193-77. PMID 8490660.
  9. ^ de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F (November 2004). "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3". The Journal of Clinical Investigation. 114 (10): 1512–7. doi:10.1172/JCI22588. PMC 525745. PMID 15546002.
  10. ^ Wong S, Moore S, Orisio S, Millward A, Demaine AG (January 1991). "Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11". Clinical and Experimental Immunology. 83 (1): 69–73. doi:10.1111/j.1365-2249.1991.tb05590.x. PMC 1535466. PMID 1671006.
  11. ^ Nakano H, Yamazaki T, Miyatake S, Nozaki N, Kikuchi A, Saito T (March 1996). "Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex". The Journal of Biological Chemistry. 271 (11): 6483–9. doi:10.1074/jbc.271.11.6483. PMID 8626450.
  12. ^ Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T (June 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". The Journal of Biological Chemistry. 274 (26): 18173–80. doi:10.1074/jbc.274.26.18173. PMID 10373416.
  13. ^ Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B (June 2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation". Cell. 109 (7): 901–12. doi:10.1016/S0092-8674(02)00799-7. PMID 12110186.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.