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AliasesCDC42EP3, BORG2, CEP3, UB1, CDC42 effector protein 3
External IDsOMIM: 606133 MGI: 2384718 HomoloGene: 4708 GeneCards: CDC42EP3
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CDC42EP3
Genomic location for CDC42EP3
Band2p22.2Start37,641,882 bp[1]
End37,738,468 bp[1]
RNA expression pattern
PBB GE CDC42EP3 209287 s at fs.png

PBB GE CDC42EP3 209286 at fs.png

PBB GE CDC42EP3 209288 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)



Location (UCSC)Chr 2: 37.64 – 37.74 MbChr 17: 79.33 – 79.36 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.[5][6][7]

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.[7]


CDC42EP3 has been shown to interact with CDC42[5][8] and RHOQ.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163171 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036533 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Alberts AS, Bouquin N, Johnston LH, Treisman R (May 1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J Biol Chem. 273 (15): 8616–22. doi:10.1074/jbc.273.15.8616. PMID 9535835.
  6. ^ Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
  7. ^ a b "Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3".
  8. ^ a b Joberty, G; Perlungher R R; Macara I G (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. ISSN 0270-7306. PMC 84628. PMID 10490598.

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