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CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass334.338 g/mol g·mol−1
3D model (JSmol)
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CGS-12066A is a drug which acts as a potent and selective agonist for the 5-HT1B receptor with lower affinity for the three 5-HT2 receptor subtypes.[1][2] It is used for studying the role of the 5-HT1B receptor in various processes including perception of pain and the sleep-wake cycle.[3][4]


  1. ^ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 2004 Aug;370(2):114-23. doi:10.1007/s00210-004-0951-4 PMID 15322733
  2. ^ Jeong HS, Jang MJ, Park JS. Effects of CGS-12066A on medial vestibular nuclear neurons. Brain Research. 15 March 2005;1038(1):118-21. PMID 15748881
  3. ^ Monti JM, Jantos H. The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. Progress in Brain Research. 2008;172:625-46. PMID 18772053
  4. ^ Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 20 January 2010;165(2):561-8. PMID 19837141