|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||304.774 g/mol g·mol−1|
|3D model (JSmol)|
|NY (what is this?)|
CP-809101 is a drug which acts as a potent and selective 5-HT2C receptor agonist. It had promising results in animal models of obesity and psychosis, but associated with genotoxicity which means that future use will be restricted to scientific research applications only.
- Strong PV, Greenwood BN, Fleshner M (May 2009). "The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats". Psychopharmacology. 203 (4): 665–75. doi:10.1007/s00213-008-1413-3. PMID 19037632.
- Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA (February 2007). "CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity". Neuropharmacology. 52 (2): 279–90. doi:10.1016/j.neuropharm.2006.07.024. PMID 16949622.
- Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K (June 2007). "Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation". Drug Metabolism and Disposition. 35 (6): 848–58. doi:10.1124/dmd.106.013649. PMID 17344339.
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