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AliasesCREB3, LUMAN, LZIP, sLZIP, cAMP responsive element binding protein 3
External IDsOMIM: 606443 MGI: 99946 HomoloGene: 31375 GeneCards: CREB3
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for CREB3
Genomic location for CREB3
Band9p13.3Start35,732,598 bp[1]
End35,736,999 bp[1]
RNA expression pattern
PBB GE CREB3 209432 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 9: 35.73 – 35.74 MbChr 4: 43.56 – 43.57 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.[5][6]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.[6]

See also[edit]


CREB3 has been shown to interact with Host cell factor C1.[7][8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107175 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028466 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lu R, Yang P, O'Hare P, Misra V (Sep 1997). "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor". Mol Cell Biol. 17 (9): 5117–26. doi:10.1128/MCB.17.9.5117. PMC 232362. PMID 9271389.
  6. ^ a b "Entrez Gene: CREB3 cAMP responsive element binding protein 3".
  7. ^ Lu, R; Yang P; Padmakumar S; Misra V (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. 72 (8): 6291–7. ISSN 0022-538X. PMC 109766. PMID 9658067.
  8. ^ Freiman, R N; Herr W (Dec 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. ISSN 0890-9369. PMC 316754. PMID 9389645.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.