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AliasesCRIPT, SSMDF, HSPC139, CXXC repeat containing interactor of PDZ3 domain
External IDsOMIM: 604594 MGI: 1929655 HomoloGene: 8572 GeneCards: CRIPT
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CRIPT
Genomic location for CRIPT
Band2p21Start46,616,416 bp[1]
End46,625,742 bp[1]
RNA expression pattern
PBB GE CRIPT 218643 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 46.62 – 46.63 MbChr 17: 87.03 – 87.04 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.[5][6][7][8][9]


CRIPT has been shown to interact with DLG3.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119878 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024146 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). "The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins". J Biochem. 138 (2): 177–82. doi:10.1093/jb/mvi107. PMID 16091592.
  6. ^ Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). "The PDZ1 domain of SAP90. Characterization of structure and binding". J Biol Chem. 277 (9): 6967–73. doi:10.1074/jbc.M109453200. PMID 11744724.
  7. ^ Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). "Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95". Nat Neurosci. 2 (12): 1063–9. doi:10.1038/15990. PMID 10570482.
  8. ^ Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762.
  9. ^ "Entrez Gene: CRIPT cysteine-rich PDZ-binding protein".
  10. ^ Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. United States. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. ISSN 0021-9258. PMID 11937501.

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