Carboxypeptidase A2

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Protein CPA2 PDB 1aye.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesCPA2, carboxypeptidase A2
External IDsMGI: 3617840 HomoloGene: 37541 GeneCards: CPA2
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CPA2
Genomic location for CPA2
Band7q32.2Start130,266,863 bp[1]
End130,289,798 bp[1]
RNA expression pattern
PBB GE CPA2 206212 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 130.27 – 130.29 MbChr 6: 30.54 – 30.56 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene.[5][6][7]

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158516 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071553 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Catasus L, Vendrell J, Aviles FX, Carreira S, Puigserver A, Billeter M (Apr 1995). "The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model". J Biol Chem. 270 (12): 6651–7. doi:10.1074/jbc.270.12.6651. PMID 7896805.
  6. ^ Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
  7. ^ a b "Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)".

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M14.002
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Carboxypeptidase A2