Cardiotrophin 1

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cardiotrophin 1
Identifiers
SymbolCTF1, CT1, CT-1
NCBI gene1489
HGNC2499
OMIM600435
RefSeqNM_001330
UniProtQ16619
Other data
LocusChr. 16 p11.2-16p11.1

Cardiotrophin-1 (CT-1) is a cytokine. It is a cardiac hypertrophic factor of 21.5 kDa and a protein member of the IL-6 cytokine family.

Pathology[edit]

CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.

Mode of action[edit]

The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.

CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. [1]


References[edit]

  1. ^ "Recombinant human Cardiotrophin 1 protein (ab9838)". www.abcam.com. Retrieved 2017-08-09.

External links[edit]