3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||407.62 g·mol−1|
|Density||0.543 g/ml tapped bulk density|
|Melting point||100 to 101 °C (212 to 214 °F; 373 to 374 K)|
|GHS signal word||Danger|
|H302, H320, H331, H371, H373, H400, H410|
|P260, P261, P264, P270, P271, P273, P301+312, P304+340, P305+351+338, P309+311, P311, P314, P321, P330, P337+313, P391, P403+233, P405, P501|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Chlorfenapyr is a pesticide, and specifically a pro-insecticide (meaning it is metabolized into an active insecticide after entering the host), derived from a class of microbially produced compounds known as halogenated pyrroles. The United States Environmental Protection Agency initially denied registration in 2000 for use on cotton primarily because of concerns that the insecticide was toxic to birds and because effective alternatives were available. However, it was registered by EPA in January, 2001 for use on non-food crops in greenhouses. In 2005, EPA established a tolerance for residues of chlorfenapyr in or on all food commodities. Chlorfenapyr works by disrupting the production of adenosine triphosphate, specifically, "Oxidative removal of the N-ethoxymethyl group of chlorfenapyr by mixed function oxidases forms the compound CL 303268. CL 303268 uncouples oxidative phosphorylation at the mitochondria, resulting in disruption of production of ATP, cellular death, and ultimately organism mortality."
Chlorfenapyr is also used as a wool insect-proofing agent, and was introduced as an alternative to synthetic pyrethroids due to a lower toxicity to mammalian and aquatic life.
- Ingham, P. E.; McNeil, S. J.; Sunderland, M. R. (2012). "Functional finishes for wool – Eco considerations". Advanced Materials Research. 441: 33–43.
- Fred Barbash (May 6, 2016). "31 people suddenly dropped dead in a Pakistani village. Now police claim to know the horrible reason why". Washington Post.
This article includes a list of references, but its sources remain unclear because it has insufficient inline citations. (June 2016) (Learn how and when to remove this template message)
- US EPA (2001). "Pesticide Fact Sheet: Chlorfenapyr" (PDF). Retrieved 2014-09-09.
- US EPA (2000). "Decision Memorandum: Denial of Registration of Chlorfenapyr for Use on Cotton" (PDF). Retrieved 2006-07-28.