|Synonyms||Calmactin; KC 9946|
|Elimination half-life||1.6 - 1.9 hours|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||319.408 g·mol−1|
|3D model (JSmol)|
5-HT3 receptors are responsible for causing many things from nausea to excess bowel movements. In conditions such as irritable bowel syndrome (IBS), the receptors have become faulty or oversensitive. 5-HT3 antagonists work by blocking the nervous and chemical signals from reaching these receptors.
Studies have shown that the drug can improve quality of life in men and women with diarrhea-predominant IBS. Cilansetron is the first 5-HT antagonist specifically designed for IBS that is effective in men as well as women.