Clofedanol

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Clofedanol
Clofedanol.svg
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
Oral
ATC code
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.011.219 Edit this at Wikidata
Chemical and physical data
FormulaC17H20ClNO
Molar mass289.8 g/mol g·mol−1
3D model (JSmol)
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Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.[1] It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009.[2] Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process[3] and its safety and efficacy data are limited.

Synthesis[edit]

Clofedanol synthesis: R. Lorenz and H. Henecka, U.S. Patent 3,031,377 (1962).

See also[edit]

References[edit]

  1. ^ "Clofedanol" (in French). BIAM. 1998-07-24. Retrieved 2007-04-15.
  2. ^ "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. Retrieved 2009-09-27.
  3. ^ "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.